"Understanding (a little of) the Genome: What turns genes on"

11/19/1999: [time not recorded]
[location not recorded]

Abstract: The talk will begin with a short review of the necessary biological knowledge so that both the significance of locating binding sites and the constraints of biological fidelity are understood. Our approach towards finding binding sites relies on two major steps. First, we form families of co-regulated genes by clustering the gene expression data which we get from the Affymetrix gene chip machine. Next, using the family of co-regulated genes, we carry out a stochastic hill-climbing search over the upstream region of the genes for the binding sites. Through this procedure we have rediscovered known binding sites and suggested additional candidate binding sites.

Last updated: Mon Jun 19 17:44:06 2006