Jose-Luis Ambite

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains

TitleA Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains
Publication TypeJournal Article
Year of Publication2011
AuthorsC. L. Avery, Q. He, K. E. North, J. L. Ambite, E. Boerwinkle, M. Fornage, L. A. Hindorff, C. Kooperberg, J. B. Meigs, J. S. Pankow, S. A. Pendergrass, B. M. Psaty, M. D. Ritchie, J. I. Rotter, K. D. Taylor, L. R. Wilkens, G. Heiss, and D. Y. Lin
JournalPLoS Genet
Pagese1002322
Date Published10
Abstract

Author Summary

The metabolic syndrome represents a clustering of metabolic phenotypes (e.g. elevated blood pressure, cholesterol levels, and plasma glucose, as well as abdominal obesity) and is associated with an increased risk of atherosclerosis and type 2 diabetes. Although multiple genes influencing the specific metabolic syndrome components have been reported, few studies have evaluated the genetic underpinnings of the syndrome as a whole. Here, we describe an approach to evaluate multiple clustered traits, which allows us to test whether common genetic variants influence the co-occurrence of one or more metabolic phenotypes. By examining approximately 20,000 European American and 6,200 African American participants from five studies, we show that three regions on chromosomes 12, 19, and 20 are associated with multiple metabolic phenotypes. These genetic variants are highly intriguing candidates that may increase our understanding of the biologic basis of the clustering of metabolic phenotypes and help identify targets for early intervention.

URLhttp://dx.doi.org/10.1371%2Fjournal.pgen.1002322
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