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Note: Typical usage: bind-01 :ARG4 binding-affinity-91
Note: Typical values for binding-affinity-91 :ARG1 include: acid-dissociation-constant (Ka), affinity-constant (Ka), dissociation-constant (Kd), inhibitor-constant (Ki), michaelis-constant (Km), power-of-dissociation-constant (pKd), power-of-inhibitor-constant (pKi)
Note: See AMR Dict entry for binding-affinity-91 for full AMR examples
- "quantification of how strong molecules bind to each other"
ARG1: binding affinity constant measured (e.g. dissociation-constant (Kd), inhibitor-constant (Ki))
ARG2: binding affinity quantity (e.g. concentration-quantity such as '5 nanomolar')
Example - "Kd"
Gefitinib binds wild-type EGFR kinase with Kd = 53.5 nM.
ARG2: 53.5 nM
Note: Normalize Kd to dissociation-constant.
Example - "Ki"
TKI258 binds tightly to the FGFR1 KD V561M (Ki ~ 35 nM).
ARG2: 35 nM
Note: Normalize Ki to inhibitor-constant.