Abstract

Background: Multiple primary cancers account for approximately 16% of all incident cancers in the United States. Although genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these genetic variants with risk of multiple primary cancers (MPC).
Methods: As part of the National Human Genome Research Institute (NHGRI) Population Architecture using Genomics and Epidemiology (PAGE) study, we used data from the Multiethnic Cohort (MEC) and Women's Health Initiative (WHI). Incident MPC (IMPC) cases (n = 1,385) were defined as participants diagnosed with more than one incident cancer after cohort entry. Participants diagnosed with only one incident cancer after cohort entry with follow-up equal to or longer than IMPC cases served as controls (single-index cancer controls; n = 9,626). Fixed …

Date

2014

Authors

S Lani Park, Christian P Caberto, Yi Lin, Robert J Goodloe, Logan Dumitrescu, Shelly-Ann Love, Tara C Matise, Lucia A Hindorff, Jay H Fowke, Fredrick R Schumacher, Jennifer Beebe-Dimmer, Chu Chen, Lifang Hou, Fridtjof Thomas, Ewa Deelman, Ying Han, Ulrike Peters, Kari E North, Gerardo Heiss, Dana C Crawford, Christopher A Haiman, Lynne R Wilkens, William S Bush, Charles Kooperberg, Iona Cheng, Loïc Le Marchand

Journal

Cancer Epidemiology, Biomarkers & Prevention

Volume

23

Issue

11

Pages

2568-2578

Publisher

American Association for Cancer Research