Abstract

Background
Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed.
Methods
We included 18023 patients with lung cancer and 60543 control subjects from two consortia, Population Architecture using Genomics and Epidemiology (PAGE) and Transdisciplinary Research in Cancer of the Lung (TRICL). We examined 165 single-nucleotide polymorphisms (SNPs) that were previously associated with at least one of 16 non–lung cancer sites. Study-specific logistic regression results underwent meta-analysis, and associations were also examined by race/ethnicity, histological cell type, sex, and …

Date

2014

Authors

S Lani Park, Megan D Fesinmeyer, Maria Timofeeva, Christian P Caberto, Jonathan M Kocarnik, Younghun Han, Shelly-Ann Love, Alicia Young, Logan Dumitrescu, Yi Lin, Robert Goodloe, Lynne R Wilkens, Lucia Hindorff, Jay H Fowke, Cara Carty, Steven Buyske, Frederick R Schumacher, Anne Butler, Holli Dilks, Ewa Deelman, Michele L Cote, Wei Chen, Mala Pande, David C Christiani, John K Field, Heike Bickebӧller, Angela Risch, Joachim Heinrich, Paul Brennan, Yufei Wang, Timothy Eisen, Richard S Houlston, Michael Thun, Demetrius Albanes, Neil Caporaso, Ulrike Peters, Kari E North, Gerardo Heiss, Dana C Crawford, William S Bush, Christopher A Haiman, Maria Teresa Landi, Rayjean J Hung, Charles Kooperberg, Christopher I Amos, Loïc Le Marchand, Iona Cheng

Journal

Journal of the National Cancer Institute

Volume

106

Issue

4

Pages

dju061

Publisher

Oxford University Press