Abstract

A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations. Rs2231142 was genotyped in 22,734 European Americans, 9,720 African Americans, 3,849 Mexican Americans, and 3,550 American Indians in the Population Architecture using Genomics and Epidemiology (PAGE) Study (2008–2012). Rs2231142 was significantly associated with serum uric acid levels (P = 2.37 × 10−67, P = 3.98 × 10−5, P = 6.97 × 10−9, and P = 5.33 × 10−4 in European Americans, African Americans, Mexican Americans, and American Indians, respectively) and gout (P = 2.83 × 10−10, P = 0.01, and P = 0.01 in European Americans, African Americans, and Mexican …

Date

2013

Authors

Lili Zhang, Kylee L Spencer, V Saroja Voruganti, Neal W Jorgensen, Myriam Fornage, Lyle G Best, Kristin D Brown-Gentry, Shelley A Cole, Dana C Crawford, Ewa Deelman, Nora Franceschini, Angelo L Gaffo, Kimberly R Glenn, Gerardo Heiss, Nancy S Jenny, Anna Kottgen, Qiong Li, Kiang Liu, Tara C Matise, Kari E North, Jason G Umans, WH Linda Kao

Journal

American journal of epidemiology

Volume

177

Issue

9

Pages

923-932

Publisher

Oxford University Press