Abstract

The effects of interleukin-33 (IL-33) on the immune system have been clearly demonstrated; however, in cardiovascular diseases, especially in coronary artery disease (CAD), these effects have not yet been clarified. In this study, we investigate the genetic role of the IL-33-ST2L pathway in CAD. We performed three-stage case-control association analyses on a total of 4,521 individuals with CAD and 4,809 controls via tag SNPs in the genes encoding IL-33 and ST2L-IL-1RL1. One tag SNP in each gene was significantly associated with CAD (rs7025417T in IL33, padj = 1.19 × 10−28, OR=1.39, 95% CI: 1.31–1.47; rs11685424G in IL1RL1, padj = 6.93 × 10−30, OR=1.40, 95% CI: 1.32–1.48). Combining significant variants in two genes, the risk for CAD increased nearly 5-fold (padj = 8.90 × 10−21, OR=4.98, 95% CI: 3.56–6.97). Traditional risk factors for CAD were adjusted for the association studies by SPSS with …

Date

2013

Authors

Xin Tu, Shaofang Nie, Yuhua Liao, Hongsong Zhang, Qian Fan, Chengqi Xu, Ying Bai, Fan Wang, Xiang Ren, Tingting Tang, Ni Xia, Sisi Li, Yuan Huang, Juan Liu, Qing Yang, Yuanyuan Zhao, Qiulun Lv, Qingxian Li, Yue Li, Yunlong Xia, Jin Qian, Bin Li, Gang Wu, Yanxia Wu, Yan Yang, Qing K Wang, Xiang Cheng

Journal

The American Journal of Human Genetics

Volume

93

Issue

4

Pages

652-660

Publisher

Elsevier