Abstract

Objective
Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be associated with colorectal cancer. In a large-scale study, we examined 171 SNPs previously associated with 18 different cancers for their associations with colorectal cancer.
Design
We examined 13 338 colorectal cancer cases and 40 967 controls from three consortia: Population Architecture using Genomics and Epidemiology (PAGE), Genetic Epidemiology of Colorectal Cancer (GECCO), and the Colon Cancer Family Registry (CCFR). Study-specific logistic regression results, adjusted for age, sex …

Date

May 1, 2014

Authors

Iona Cheng, Jonathan M Kocarnik, Logan Dumitrescu, Noralane M Lindor, Jenny Chang-Claude, Christy L Avery, Christian P Caberto, Shelly-Ann Love, Martha L Slattery, Andrew T Chan, John A Baron, Lucia A Hindorff, Sungshim Lani Park, Fredrick R Schumacher, Michael Hoffmeister, Peter Kraft, Anne M Butler, David J Duggan, Lifang Hou, Chris S Carlson, Kristine R Monroe, Yi Lin, Cara L Carty, Sue Mann, Jing Ma, Edward L Giovannucci, Charles S Fuchs, Polly A Newcomb, Mark A Jenkins, John L Hopper, Robert W Haile, David V Conti, Peter T Campbell, John D Potter, Bette J Caan, Robert E Schoen, Richard B Hayes, Stephen J Chanock, Sonja I Berndt, Sebastien Küry, Stephane Bézieau, Jose Luis Ambite, Gowri Kumaraguruparan, Danielle M Richardson, Robert J Goodloe, Holli H Dilks, Paxton Baker, Brent W Zanke, Mathieu Lemire, Steven Gallinger, Li Hsu, Shuo Jiao, Tabitha A Harrison, Daniela Seminara, Christopher A Haiman, Charles Kooperberg, Lynne R Wilkens, Carolyn M Hutter, Emily White, Dana C Crawford, Gerardo Heiss, Thomas J Hudson, Hermann Brenner, William S Bush, Graham Casey, Loïc Le Marchand, Ulrike Peters

Journal

Gut

Volume

63

Issue

5

Pages

800-807

Publisher

BMJ Publishing Group