Abstract

Background
C-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes mellitus, and obesity. We aimed to replicate previous CRP–SNP associations, assess whether these associations generalize to additional race/ethnicity groups, and evaluate inflammation-related SNPs for a potentially pleiotropic association with CRP.
Methods and Results
We selected and analyzed 16 CRP-associated and 250 inflammation-related GWAS SNPs among 40 473 African American, American Indian, Asian/Pacific Islander, European American, and Hispanic participants from 7 studies collaborating in the Population Architecture using Genomics and Epidemiology (PAGE) study. Fixed-effect meta-analyses combined study …

Date

January 1, 1970

Authors

Jonathan M Kocarnik, Sarah A Pendergrass, Cara L Carty, James S Pankow, Fredrick R Schumacher, Iona Cheng, Peter Durda, José Luis Ambite, Ewa Deelman, Nancy R Cook, Simin Liu, Jean Wactawski-Wende, Carolyn Hutter, Kristin Brown-Gentry, Sarah Wilson, Lyle G Best, Nathan Pankratz, Ching-Ping Hong, Shelley A Cole, V Saroja Voruganti, Petra Bůžková, Neal W Jorgensen, Nancy S Jenny, Lynne R Wilkens, Christopher A Haiman, Laurence N Kolonel, Andrea LaCroix, Kari North, Rebecca Jackson, Loic Le Marchand, Lucia A Hindorff, Dana C Crawford, Myron Gross, Ulrike Peters

Journal

Circulation: Cardiovascular Genetics

Volume

7

Issue

2

Pages

178-188

Publisher

Lippincott Williams & Wilkins