Abstract

Background
Multiple genome-wide association studies (GWAS) within European populations have implicated common genetic variants associated with insulin and glucose concentrations. In contrast, few studies have been conducted within minority groups, which carry the highest burden of impaired glucose homeostasis and type 2 diabetes in the U.S.
Methods
As part of the 'Population Architecture using Genomics and Epidemiology (PAGE) Consortium, we investigated the association of up to 10 GWAS-identified single nucleotide polymorphisms (SNPs) in 8 genetic regions with glucose or insulin concentrations in up to 36,579 non-diabetic subjects including 23,323 European Americans (EA) and 7,526 African Americans (AA), 3,140 Hispanics, 1,779 American Indians (AI), and 811 Asians. We estimated the association between each SNP and fasting …

Date

January 1, 1970

Authors

Megan D Fesinmeyer, James B Meigs, Kari E North, Fredrick R Schumacher, Petra Bůžková, Nora Franceschini, Jeffrey Haessler, Robert Goodloe, Kylee L Spencer, Venkata Saroja Voruganti, Barbara V Howard, Rebecca Jackson, Laurence N Kolonel, Simin Liu, JoAnn E Manson, Kristine R Monroe, Kenneth Mukamal, Holli H Dilks, Sarah A Pendergrass, Andrew Nato, Peggy Wan, Lynne R Wilkens, Loic Le Marchand, José Luis Ambite, Steven Buyske, Jose C Florez, Dana C Crawford, Lucia A Hindorff, Christopher A Haiman, Ulrike Peters, James S Pankow

Journal

BMC medical genetics

Volume

14

Pages

1-8

Publisher

BioMed Central