Abstract

FRI-509 Drug induced liver injury-A study on the factors affecting severity and prognosis with special emphasis on metabolic syndrome S. Narayanan, K. Devadas. Trivandrum Medical College Thiruvananthapuram, India Email:[email protected] Background and Aims: The factors predicting outcome in DILI has not been well understood. Of late several studies have linked DILI severity with underlying NASH as both the disorders has been linked with mitochondrial dysfunction. Objective of the study was to whether metabolic syndrome is an independent predictive factor for severity and mortality in drug induced liver injury. Secondary objective was to identify other factors influencing outcome. Method: Severe DILI was defined as either INR> 1.5 or Ascites or hepatic encephalopathy or other organ failure. Metabolic Syndrome was defined by IDF Criteria. Inclusion criteria: Documented exposure to drug ingestion …

Date

April 1, 2018

Authors

S Narayanan, K Devadas

Journal

Journal of Hepatology

Volume

68

Pages

S592

Publisher

Elsevier