Abstract

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing are affected. We investigate how depression alters the temporal dynamics of emotional processing by measuring neural responses to self-referential affective sentences using surface electroencephalography (EEG) in healthy and depressed individuals. Our results reveal significant group-level differences in neural activity during sentence viewing, suggesting disrupted integration of emotional and self-referential information in depression. Deep learning model trained on these responses achieves an area under the receiver operating curve (AUC) of 0.707 in distinguishing healthy from depressed participants, and 0.624 in differentiating depressed subgroups with and without suicidal ideation. Spatial ablations highlight anterior electrodes associated with semantic and affective processing as key contributors. These findings suggest stable, stimulus-driven neural signatures of depression that may inform future diagnostic tools.

Date

June 6, 2025

Authors

Aditya Kommineni, Woojae Jeong, Kleanthis Avramidis, Colin McDaniel, Myzelle Hughes, Thomas McGee, Elsi Kaiser, Kristina Lerman, Idan A Blank, Dani Byrd, Assal Habibi, B Rael Cahn, Sudarsana Kadiri, Takfarinas Medani, Richard M Leahy, Shrikanth Narayanan

Journal

arXiv preprint arXiv:2506.06244